Eurasian Journal of Biosciences

Dimensions change and left ventricular function carvedilol post therapy due to heart failure cases in children with congenital heart disease left-to-right
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2020 - Volume 14 Issue 2, pp. 3697-3701
  • Published Online: 30 Sep 2020
  • Open Access Full Text (PDF)


Background: Congenital Heart Disease (CHD) is the most common congenital disorder in newborns with a prevalence of 9.1 per 1000 live births. In left-to-right PJB shunts occur excessive volume burden on the ventricles, resulting in heart failure.
Purpose: Knowing the difference in changes in the dimensions and function of the left ventricle on echocardiography after standard therapy plus placebo with the standard therapy group plus carvedilol in children with heart failure due to left-to-right CHD.
Method: Using a Randomized Controlled Trial (RCT) research design by giving a Double Blind Study treatment. Research data including comparison of initial data and final data of the two groups were analyzed by independent sample t test.
Result: The results of measurement of left ventricular mass showed a significant decrease to 40.56 ± 23.63 g / m2 (p <0.001). There was a significant decrease in left ventricular volume to 42.23 ± 20.36 m3 (p = 0.05). There was a significant increase in the mean left ventricular ejection fraction to 74.16 ± 4.10% (p = 0.03). There was an increase in the left ventricular shortening fraction to 42.18 ± 3.66% (p = 0.04).
Conclusion: There are differences in the dimensions of the left ventricular at the end of systolic (DVKI-AS), the left ventricle at the end of diastolic (VKI-AD), the thickness of the back wall of the left ventricle at the end of diastolic (DBVKI-AD), and the thickness of the interventricular septum at the end of diastolic (SIV-AD).


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